Nanocarriers for Effective Brain Drug Delivery

ÇOMOĞLU T., ARISOY S., Akkus Z. B.

CURRENT TOPICS IN MEDICINAL CHEMISTRY, cilt.17, sa.13, ss.1490-1506, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 17 Sayı: 13
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1568026616666161222101355
  • Dergi Adı: CURRENT TOPICS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1490-1506
  • Anahtar Kelimeler: Blood-brain barrier, Brain drug delivery, Chemical structures of nanocarriers, Nanosized drug delivery systems, Particle size, Surface charge, Surface coating agents, Targeting ligands., SOLID LIPID NANOPARTICLES, CNS MICROVASCULAR PERICYTE, CENTRAL-NERVOUS-SYSTEM, PEG-PLA NANOPARTICLES, PLGA NANOPARTICLES, POLYMERIC NANOPARTICLES, GOLD NANOPARTICLES, TARGETED DELIVERY, IN-VITRO, CHITOSAN NANOPARTICLES
  • Ankara Üniversitesi Adresli: Evet

Özet

Drug delivery to the brain is an engaged research topic in the field of nanomedicine. The passage of therapeutics into the brain parenchyma is more complicated than other body tissues due to it is limited by restrict barrier structure called blood-brain barrier (BBB). Nanotechnology holds great promise to overcome the BBB and thereby enable treatment of neurodegenerative diseases. Nanocarriers have been investigated several times as effective brain drug delivery systems in the past few decades.