Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol

PEKTAŞ M. B., YÜCEL TENEKECİ G., KOCA H. B., SADİ G., Yildirim O. G., Ozturk G., ...Daha Fazla

DRUG RESEARCH, cilt.67, sa.2, ss.103-110, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1055/s-0042-118386
  • Dergi Adı: DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.103-110
  • Anahtar Kelimeler: fructose, resveratrol, hepatic degeneration, eNOS, IRS-1, TNF alpha, IL-1 beta, FATTY LIVER-DISEASE, PLASMINOGEN-ACTIVATOR INHIBITOR-1, REDUCES INSULIN-RESISTANCE, EXPRESSION, STEATOHEPATITIS, INFLAMMATION, DYSFUNCTION, PROTEIN, MICE
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose: Relatively little is known about gender-dependent susceptibility to hepatic injury induced by nutritional factors. In the current study, we investigated dietary fructose-induced hepatic degeneration and roles of endothelial nitric oxide synthase (eNOS), insulin receptor (IR beta) and substrate-1 (IRS-1) expressions in association with inflammatory markers in male and female rats. Moreover, we examined potential effect of resveratrol on fructose-induced changes.