Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol
DRUG RESEARCH, cilt.67, sa.2, ss.103-110, 2017 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 Sayı: 2
- Basım Tarihi: 2017
- Doi Numarası: 10.1055/s-0042-118386
- Dergi Adı: DRUG RESEARCH
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.103-110
- Anahtar Kelimeler: fructose, resveratrol, hepatic degeneration, eNOS, IRS-1, TNF alpha, IL-1 beta, FATTY LIVER-DISEASE, PLASMINOGEN-ACTIVATOR INHIBITOR-1, REDUCES INSULIN-RESISTANCE, EXPRESSION, STEATOHEPATITIS, INFLAMMATION, DYSFUNCTION, PROTEIN, MICE
- Ankara Üniversitesi Adresli: Evet
Özet
Purpose: Relatively little is known about gender-dependent susceptibility to hepatic injury induced by nutritional factors. In the current study, we investigated dietary fructose-induced hepatic degeneration and roles of endothelial nitric oxide synthase (eNOS), insulin receptor (IR beta) and substrate-1 (IRS-1) expressions in association with inflammatory markers in male and female rats. Moreover, we examined potential effect of resveratrol on fructose-induced changes.