How conformational transition depends on hydrophobicity of elastin-like polypeptides

Arkin H., Bilsel M.

EUROPEAN PHYSICAL JOURNAL E, cilt.31, sa.3, ss.327-332, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1140/epje/i2010-10573-7
  • Dergi Adı: EUROPEAN PHYSICAL JOURNAL E
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.327-332
  • Ankara Üniversitesi Adresli: Evet

Özet

The three-dimensional structures of elastin-like polypeptides Val1-Pro2-Gly3-Xaa4-Gly5 were investigated by using the multicanonical Monte Carlo (MC) simulation procedure. By substituting different amino acids in the fourth position of the sequence, the thermodynamical variables are calculated in vacuo and in solvent to determine the hydrophobicity dependence of the conformational transition temperatures of the peptides. Resultant hydrophobicity scale is in good agreement with many hydrophobicity scales.