TNF-alpha-308G/A and IL-6-174 G/C polymorphisms in the Turkish pediatric stroke patients

KARAHAN Z. C., Deda G., Sipahi T., ELHAN A. H., Akar N.

THROMBOSIS RESEARCH, cilt.115, sa.5, ss.393-398, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 115 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.thromres.2004.09.008
  • Dergi Adı: THROMBOSIS RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.393-398
  • Anahtar Kelimeler: stroke, TNF-alpha, IL-6, promoter polymorphisms, TUMOR-NECROSIS-FACTOR, INCREASED CYTOKINE RELEASE, CENTRAL-NERVOUS-SYSTEM, INTERLEUKIN-6 GENE, ISCHEMIC-STROKE, BRAIN-INJURY, FACTOR-ALPHA, METHYLENETETRAHYDROFOLATE REDUCTASE, PROINFLAMMATORY CYTOKINES, INFLAMMATORY CYTOKINES
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Stroke is an important cause of mortality and morbidity in the pediatric age group. There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke. These proinflammatory cytokines carry functional polymorphisms (IL-6 -174 G/C and TNF-alpha -308 G/A) in their promoter regions, affecting their transcription rate and plasma cytokine levels. The aim of this study was to investigate the association of these polymorphisms with the occurrence of stroke in the Turkish pediatric stroke patients. Material and Methods: Eighty six arterial stroke. patients (aged between 0 and 14) and 83 healthy unrelated adult controls without personal or family history of stroke were investigated by PCR and restriction endonuclease analysis for IL-6 -174 G/C and TNF-alpha -308 G/A polymorphisms. Results: The allele distribution, allele frequencies, and combined distribution of genotypes for both polymorphisms did not differ significantly between control and patient groups. Conclusions: The two polymorphisms did not associate with the occurrence of stroke in our study group. (C) 2004 Elsevier Ltd. All rights reserved.