Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver


Akbiyik F., Cinar K., Demirpence E., Ozsullu T., Tunca R., Haziroglu R., ...More

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.34, no.6, pp.429-435, 2004 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 34 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1365-2362.2004.01359.x
  • Journal Name: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.429-435
  • Keywords: fatty liver, mitochondrial beta-oxidation, oxidative injury, peroxisomal beta-oxidation, PPAR alpha, ACYL-COA OXIDASE, BETA-OXIDATION, PPAR-ALPHA, GENE, EICOSANOIDS, STEATOHEPATITIS, MECHANISMS, ISOFORM
  • Ankara University Affiliated: No

Abstract

Background Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates lipid metabolism upon activation by ligands. Peroxisome proliferator-activated receptor alpha may play a role in the pathogenesis of fatty liver disease. The aim of this study was to assess the PPARalpha expression pattern and mitochondrial/peroxisomal enzyme activities in response to high fat diet (HFD) and clofibrate, a well known PPARalpha ligand.