Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, cilt.34, sa.6, ss.429-435, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 6
- Basım Tarihi: 2004
- Doi Numarası: 10.1111/j.1365-2362.2004.01359.x
- Dergi Adı: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.429-435
- Anahtar Kelimeler: fatty liver, mitochondrial beta-oxidation, oxidative injury, peroxisomal beta-oxidation, PPAR alpha, ACYL-COA OXIDASE, BETA-OXIDATION, PPAR-ALPHA, GENE, EICOSANOIDS, STEATOHEPATITIS, MECHANISMS, ISOFORM
- Ankara Üniversitesi Adresli: Hayır
Özet
Background Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates lipid metabolism upon activation by ligands. Peroxisome proliferator-activated receptor alpha may play a role in the pathogenesis of fatty liver disease. The aim of this study was to assess the PPARalpha expression pattern and mitochondrial/peroxisomal enzyme activities in response to high fat diet (HFD) and clofibrate, a well known PPARalpha ligand.