The role of vulpinic acid as a natural compound in the regulation of breast cancer-associated miRNAs

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CANSARAN DUMAN D., Yangin S., Colak B.

BIOLOGICAL RESEARCH, cilt.54, sa.1, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1186/s40659-021-00360-4
  • Dergi Adı: BIOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: Vulpinic acid, microRNA analysis, Breast cancer, GENE-EXPRESSION, CELL-GROWTH, IN-VITRO, APOPTOSIS, PACLITAXEL, MICRORNA, BIOMARKERS, RESISTANCE, CURCUMIN
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Breast cancer is the most frequently diagnosed cancer, and no effective treatment solution has yet been found. The number of studies based on the research of novel natural compounds in the treatment of breast cancer has been increasing in recent years. The anticancer properties of natural compounds are related to the regulation of microRNA (miRNA) expression. Therefore, changing the profile of miRNAs with the use of natural products is very important in cancer treatment. However, the role of vulpinic acid and related miRNAs in breast cancer progression remains unknown. Vulpinic acid, methyl (as2E)-2-(3-hydroxy-5-oxo-4-phenylfuran-2-ylidene)-2 phenylacetate, is a natural product extracted from the lichen species and shows an anticancer effect on different cancer cells.