Preparation and characterization of polymeric micelles as drug carrier system İlaç taşiyici si̇stemler olarak poli̇meri̇k mi̇selleri̇n hazirlanmasi ve karakteri̇zasyonu

Sezgin Z., YÜKSEL N., Baykara T.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.32, sa.2, ss.125-142, 2003 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 32 Sayı: 2
  • Basım Tarihi: 2003
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.125-142
  • Anahtar Kelimeler: Amphiphilic co-polymers, Contrast agent, Critical micelle concentration, Drug carrier system, Drug targeting, Poymeric micelles
  • Ankara Üniversitesi Adresli: Evet

Özet

This review concentrates on the use of polymeric micelles as pharmaceutical carriers in recent years. The structure and properties of the amphiphilic block co-polymers that form stable polymeric micelles having high loading capasity towards poorly soluble pharmaceuticals are described. General information on the mechanisms of micelle formation and drug loading process is given. Characterization and advantages of micelles are considered. The last section of the review focuses on the potential medical applications of polymeric micelles in medical diagnostic imaging, drug targeting, immunology, gene therapy and oral drug delivery.