Akademik Veri Yönetim Sistemi
EURASIAN JOURNAL OF PULMONOLOGY, sa.3, ss.169-172, 2013 (ESCI)
Objective: Proton pump inhibitors (PPIs) are the primary drugs with proven efficacy in gastrointestinal diseases. The effectiveness of these drugs causes unneccessary use and potential risks. The aim of the study was to evaluate the rates of PPI use and its effect on the course of the disease in patients with community aqcuired pneumonia (CAP). Methods: The patients who were hospitalized due to pneumonia were asked about the use of PPIs, whether they were a current user, user in the last 3 months or never used. The rates of PPI use and the effect of PPI use on clinical and radiological improvement, duration of treatment and hospitalization, development of complication, need of intensive care unit and mortality were evaluated. Results: Sixty-eight patients were included in the study. The mean age of patients was 70.7 +/- 12.5 years. The rates of PPI use (current use, use in 3 months and never used) were as follows: 39%, 11.8% and 48.5% respectively. The duration of treatment and hospitalization, duration of clinical and radiological improvement were found longer in patients who were using PPI currently compared to never used (respectively; p=0.08, p=0.024, p=0.007, p=0.016). The rate of complications was higher in the current users than never users (14.8% vs 6.1%). Conclusion: Thirty-nine percent of the patients with CAP were using PPI currently. The course of pneumonia was more severe in this group. The unneccessary use of PPIs should be avoided in order to decrease the incidence and morbidity of CAP.