The Role of Oxidative Stress Modulators in Breast Cancer

GÜRER ORHAN H., Ince E., Konyar D., Saso L., SÜZEN S.

CURRENT MEDICINAL CHEMISTRY, cilt.25, sa.33, ss.4084-4101, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 25 Sayı: 33
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/0929867324666170711114336
  • Dergi Adı: CURRENT MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4084-4101
  • Anahtar Kelimeler: Oxidative stress, reactive oxygen species, breast cancer, oxidative stress modulators, melatonin, DNA ADDUCT FORMATION, FEMALE ACI RATS, MELATONIN RECEPTORS MT1, INDUCED CELL-DEATH, VITAMIN-C, IN-VITRO, HYDROGEN-PEROXIDE, ANTIOXIDANT ACTIVITY, EPITHELIAL-CELLS, GENE-EXPRESSION
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Latest data from International Agency for Cancer Research shows that breast cancer is the leading cancer site in women and is the leading cause of death among female cancers. Induction of reactive oxygen species (ROS) and oxidative stress as a consequence of impaired balance between prooxidants and antioxidants are suggested to be involved in induction and progression of breast cancer. Cancer cells are found to exhibit higher levels of ROS compared to normal cells. However increased antioxidant defence which balances the oxidative status within the cancer cells suggests that high ROS levels may prevent tumorigenesis via various mechanisms. These contradictory roles of ROS and oxidative stress in breast cancer let scientists investigate potential oxidative stress modulators as anticancer strategies.