Carcinosarcoma of the prostate - A case report and a possible evidence on the role of hormonal therapy
UROLOGIA INTERNATIONALIS, cilt.59, sa.1, ss.50-52, 1997 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 1
- Basım Tarihi: 1997
- Doi Numarası: 10.1159/000283018
- Dergi Adı: UROLOGIA INTERNATIONALIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.50-52
- Anahtar Kelimeler: prostate, carcinosarcoma, immunohistochemistry, hormonal therapy, progesterone receptor, PROGESTERONE, BENIGN
- Ankara Üniversitesi Adresli: Evet
Özet
A case of prostatic carcinosarcoma is presented with histopathologic and immunohistochemical characteristics. A 70-year-old man presented with a history of anti-androgen (cyproterone acetate) therapy for prostatic adenocarcinoma, Diffuse and strong staining for progesterone receptor was observed in the carcinosarcoma specimen although it-was completely negative in the previous adenocarcinoma specimen, It may be speculated that hormonal therapy might have facilitated the selection of a progesterone-dependent subclone of tumor cells with the ability of mesenchymal differentiation and that genetic instability due to p53 inactivation might have played a role in this process.