Carcinosarcoma of the prostate - A case report and a possible evidence on the role of hormonal therapy

SAK S., Orhan D., YAMAN M. Ö., Tulunay O., Ozdiler E.

UROLOGIA INTERNATIONALIS, cilt.59, sa.1, ss.50-52, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 1
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1159/000283018
  • Dergi Adı: UROLOGIA INTERNATIONALIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.50-52
  • Anahtar Kelimeler: prostate, carcinosarcoma, immunohistochemistry, hormonal therapy, progesterone receptor, PROGESTERONE, BENIGN
  • Ankara Üniversitesi Adresli: Evet

Özet

A case of prostatic carcinosarcoma is presented with histopathologic and immunohistochemical characteristics. A 70-year-old man presented with a history of anti-androgen (cyproterone acetate) therapy for prostatic adenocarcinoma, Diffuse and strong staining for progesterone receptor was observed in the carcinosarcoma specimen although it-was completely negative in the previous adenocarcinoma specimen, It may be speculated that hormonal therapy might have facilitated the selection of a progesterone-dependent subclone of tumor cells with the ability of mesenchymal differentiation and that genetic instability due to p53 inactivation might have played a role in this process.