Diverse Responses of Neurons and Monocytes to Titanium Dioxide Nanoparticle Exposure

ENGİN A. B., ENGİN E. D.

TURKISH JOURNAL OF IMMUNOLOGY, vol.7, no.1, pp.40-49, 2019 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.25002/tji.2019.1037
  • Journal Name: TURKISH JOURNAL OF IMMUNOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.40-49
  • Keywords: Titanium dioxide nanoparricle, N-acetyl cysteine, neopterin, U937 monocytic cells, SH-SY5Y neuroblastoma cells, N-methyl-D-aspartate receptors, TUMOR-NECROSIS-FACTOR, N-ACETYLCYSTEINE, OXIDATIVE STRESS, TIO2 NANOPARTICLES, GLUTAMATE METABOLISM, TOXICITY, GLUTATHIONE, EXPRESSION, NMDA, CYSTEINE
  • Ankara University Affiliated: Yes

Abstract

Introduction: The toxicity of titanium dioxide nanoparticles (TiO(2)NPs) in neurons occurs by glutamate signaling via N-methyl-d-aspartate (NMDA) receptors. Although cellular uptake of TiO(2)NPs may lead to oxidative stress in macrophages, it is nor known whether TiO(2)NPs have toxic effects on U937 monocytic cell line.