Release of cysteinyl leukotrienes with aspirin stimulation and the effect of prostaglandin E-2 on this release from peripheral blood leucocytes in aspirin-induced asthmatic patients

Celik G. E., BAVBEK S., Misirligil Z., Melli M.

CLINICAL AND EXPERIMENTAL ALLERGY, cilt.31, sa.10, ss.1615-1622, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 10
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1046/j.1365-2222.2001.01074.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL ALLERGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1615-1622
  • Anahtar Kelimeler: aspirin-induced asthma, cysteinyl leukotrienes, prostaglandin E-2, SENSITIVE ASTHMA, INDUCED BRONCHOCONSTRICTION, INHALED PROSTAGLANDIN-E2, INTOLERANT ASTHMATICS, BRONCHIAL REACTIVITY, NASAL SECRETIONS, MECHANISM, CELLS, BRONCHOSPASM, HISTAMINE
  • Ankara Üniversitesi Adresli: Evet

Özet

Background The decrease in prostaglandin E-2 (PGE(2)) release due to aspirin (ASA)induced cyclooxygenase inhibition and the increment in cysteinyl leukotriene (Cys-LT) release secondary to the removal of the inhibitory effect of PGE(2) on Cys-LT release have been suggested in the pathogenesis of aspirin-induced asthma (AIA).