Akademik Veri Yönetim Sistemi
IRANIAN JOURNAL OF PEDIATRICS, sa.5, 2017 (SCI-Expanded)
Background: Studies on various adult cancer types showed that there are changes in levels of protein types that are related to iron metabolism. In our study, proteins related to iron metabolism are examined for the first time in childhood malignancies and results are presented. Methods: Between January 2013 and December 2014, 58 patients 17 healthy children were included in the study. Blood samples were taken from patients at diagnosis and in remission and serum ferritin heavy chain (FTH-1), ferritin light chain (FTL), LCN-2, soluble transferrin receptor (sTFR), transferrin receptor-2 (TFR-2), hepcidin and ferroportin levels were examined using ELISA method. Results: Levels of FTH-1 were found higher in all patient groups than in control group (P < 0.05). Levels of FTL were found higher in all patient groups than in control group, although this was not statistically significant. It was observed that these levels decreased in remission. Levels of LCN-2 were found significantly high (P = 0.001) in all patient groups. sTfR levels were found lower in acute leukemia patients (P = 0.001). Level of TFR-2 was found to be higher in all patient groups in comparison with the control group and this was statistically significant in lymphoma group (P = 0.05). In remission, levels of TFR-2 decreased. Levels of serum hepcidin were found to be higher in all patient groups in comparison with the control group and this was statistically significant (P = 0.001). Hepcidin levels decreased in remission. Although it was not statistically significant, it was observed that levels of serum ferroportin were low in sarcoma and leukemia groups at diagnosis and increased in remission. As a result, despite the fact that our patients' number was limited, we thought that investigation of the iron metabolism of tumor cells is important and additional studies will be necessary with increasing patients' number.