Akademik Veri Yönetim Sistemi
European Journal of Immunogenetics, cilt.28, sa.2, ss.349, 2001 (SCI-Expanded)
There are markedly differences in the distribution of HLA haplotype among different populations, and multilocus HLA haplotypes can best be studied by family analysis. HLA population genetic studies have been carried out on numerous population samples, ,however , no family based study has been performed on Turkish people until now. In the present study, we have analysed the HLA-A.B,C,DR and DQ antigens and haplotypes of 327 unrelated healty Turkish individuals recruited on to the Turkish live donor registry. We calculated Hardy-Weinberg fit. phenotype and gene frequencies and two- and three- locus haplotype frequencies, linkage disequilibrium (LD) values. Most frequent allel frequencies for class-I antigens were A2, A24, A3, A1, A11, B35, B51, B44, B49, B18, Cw4, Cw7, Cw6 and those for class-II antigens were DR11, DR4, DR7, DQ7, DQ2 and DQ1. When compared to the previous data, this distribution suggested that there was a particular pattern of polymorphism of the Turkish HLA antigens. Haplotaypes B35/Cw4, B13/DR7, A11/B35, A30/B13, A2/B5 were found to have significant LD. wherase there were strong negative associations between of A2/B35, A2/B8, B35/DR17 haplotypes . Some of these antigen combinations have not been previously described The results obtained in this study may be useful as basic data of the Turks for an antropology. organ transplantation and disease susceptibility. © 2001 Blackwell Science Ltd,.