Erythrocyte oxidant/antioxidant status of diabetic patients

Buyukkocak S., ÖZTÜRK H. S., Tamer M., Kacmaz M., Cimen M., Durak I.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.23, sa.4, ss.228-230, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1007/bf03343712
  • Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.228-230
  • Anahtar Kelimeler: antioxidant potential, diabetes mellitus, erythrocyte, LIPID-PEROXIDATION, OXIDATIVE STRESS, MELLITUS
  • Ankara Üniversitesi Adresli: Evet

Özet

Present study aims to establish erythrocyte oxidant/antioxidant status in diabetic patients with and without atherosclerotic complications. Pasting blood samples were obtained from 23 diabetic and 12 control subjects. Thirteen patients had no disease other than diabetes mellitus and 10 patients had also atherosclerosis in addition to diabetes mellitus. Erythrocyte antioxidant potential (AOP) and thiobarbituric acid reagent substances (TBARS) levels were measured in these patients and results were compared with those of controls, who were chosen among healthy subjects. Results suggest that although there is an oxidant stress in the erythrocytes of diabetics, this is not due to reduced erythrocyte antioxidant defence potential but, rather, increased free radical production possibly due to hyperglycemia. (C) 2000, Editrice Kurtis.