The importance of anti-neutrophil cytoplasmic antibody in inflammatory bowel disease INFLAMATUAR BARSAK HASTALIGINDA ANTI-NOTROFIL STOPLAZMIK ANTIKORUN ONEMI

Kayatas M., Dokmeci A., KINIKLI G.

Turkish Journal of Gastroenterology, vol.8, no.1, pp.101-108, 1997 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 1997
  • Journal Name: Turkish Journal of Gastroenterology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.101-108
  • Keywords: ANCA, Inflammatory bowel disease
  • Ankara University Affiliated: Yes

Abstract

In this study, ANCA has been studied by indirect immunofluorescence (IIF) method in 46 patients with colitis ulcerosa (CU), 16 patients with Crohn's disease (CD), 24 patients with infectious colitis (IC). Forty seven point eight percent of the patients with CU have been found to be ANCA positive (41.3% p-ANCA, 6.5% c-ANCA), 12.5% of the patients with CD have been found to be ANCA, 4.2% of the patients with IC have been found to be ANCA positive (one patient, c-ANCA). The ratio of ANCA positivity in the patients with CU has been found to be statistically significantly higher compared to patients with CD and IC (p<0.001). The sensitivity and specificity of ascertaining ANCA positivity in CU patients with this method is found to be higher than that in patients with CD or IC ANCA positivity, especially p-ANCA type painting favors the diagnosis of CU. Especially, p-ANCA type painting can differentiate CU from IC definitively. For this reason, we think that, the diagnosis of the patients who are thought to be IBD or IC, it will be useful to test ANCA status by IIF method.