Scavenging capacities of some thiazolyl thiazolidine-2,4-dione compounds on superoxide radical, hydroxyl radical, and DPPH radical

Kruk I., BOZDAĞ DÜNDAR O., Ceylan-Ünlüsoy M., Ertan R., Aboul-Enein H. Y., Michalska T.

LUMINESCENCE, cilt.24, sa.4, ss.230-235, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/bio.1105
  • Dergi Adı: LUMINESCENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.230-235
  • Anahtar Kelimeler: Thiazolyl-thiazolidine-2,4-dione compounds, free radicals, scavenging capacity, HYDROGEN-PEROXIDE, DNA-DAMAGE, ANTIOXIDANT, DERIVATIVES, CHEMILUMINESCENCE, AUTOXIDATION, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

The scavenging effects of eighteen thiazolyl thiazolidine-2,4-dione compounds (TTCs) on superoxide radical O(2)radical anion hydroxyl radical HO center dot, and 1,1-diphenyl-2-picrylhydrazyl (DPPH center dot) radical were evaluated by the chemiluminescence technique, electron spin resonance spectrometry (ESR) and visible spectrophotometry, respectively. The examined compounds were shown to have 27-59% O(2)radical anion scavenging ability, 19-69% HO center dot scavenging activity and 2-32% DPPH center dot scavenging ability. This property of the tested compound seems to be important in the prevention of various diseases of free radicals etiology. Copyright (C) 2009 John Wiley & Sons, Ltd.