Akademik Veri Yönetim Sistemi
International Multidisciplinary Symposium on Drug Research and Development (DRD) 2023, İzmir, Türkiye, 4 - 06 Mayıs 2023, ss.1
Autotaxin (ATX) is a 125 kDa secreted glycoprotein and hydrolyzes lysophosphatidylcholine into lysophosphatidic acid [1]. The aim of this study was to determine whether polycystic ovary syndrome (PCOS) is associated with the alteration of serum ATX levels. In addition, the relationship between ATX and several clinical and metabolic parameters was investigated in patients with PCOS. Twenty three women with PCOS and along with 20 healthy controls were enrolled in this study. Serum ATX concentration was evaluated using enzyme-linked immunosorbent assay (ELISA). Serum concentrations of insulin, luteinizing hormone, estradiol, total testosterone and C-reactive protein were significantly higher in the PCOS group than the control group. Our results revealed that serum levels of ATX in PCOS patients were lower compared to control (p=0.028). Among PCOS patients, there were no significant correlations between serum ATX levels and biochemical features. The findings of this study suggest that serum ATX may be a significant biomarker for screening PCOS.