Antagonism of acetylcholine action in guinea-pig tracheal smooth muscle and epithelium by pirenzepine, 4-DAMP and atropine

Orer H., Guc M., Rezaki Y., Ilhan M., Kayaalp S.

Archives Internationales de Pharmacodynamie et de Therapie, cilt.305, ss.45-54, 1990 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 305
  • Basım Tarihi: 1990
  • Dergi Adı: Archives Internationales de Pharmacodynamie et de Therapie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.45-54
  • Ankara Üniversitesi Adresli: Hayır

Özet

Acetylcholine-induced guinea-pig smooth muscle contraction and epithelium-derived relaxant factor release were evaluated using guinea-pig open tracheal rings and rat anococcygeus muscle bioassay to get insight into the participation of muscarinic receptor subtypes in these responses. There was a significant difference between the two pA2 values obtained in contraction and relaxation experiments for pirenzepine, but no difference was found either for atropine or for 4-DAMP. This difference seems to be due to the participation of M1-receptors in smooth muscle contraction.