Antagonism of acetylcholine action in guinea-pig tracheal smooth muscle and epithelium by pirenzepine, 4-DAMP and atropine

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Orer H., Guc M., Rezaki Y., Ilhan M., Kayaalp S.

Archives Internationales de Pharmacodynamie et de Therapie, vol.305, pp.45-54, 1990 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 305
• Publication Date: 1990
• Journal Name: Archives Internationales de Pharmacodynamie et de Therapie
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.45-54
• Ankara University Affiliated: No

Abstract

Acetylcholine-induced guinea-pig smooth muscle contraction and epithelium-derived relaxant factor release were evaluated using guinea-pig open tracheal rings and rat anococcygeus muscle bioassay to get insight into the participation of muscarinic receptor subtypes in these responses. There was a significant difference between the two pA2 values obtained in contraction and relaxation experiments for pirenzepine, but no difference was found either for atropine or for 4-DAMP. This difference seems to be due to the participation of M1-receptors in smooth muscle contraction.