The effects of sodium butyrate and inulin supplementation on angiotensin signaling pathway via promotion of Akkermansia muciniphila abundance in type 2 diabetes; A randomized, double-blind, placebo-controlled trial

Roshanravan, Neda; Mahdavi, Reza; Alizadeh, Effat; Ghavami, Abed; Saadat, Yalda; Alamdari, Naimeh; Alipour, Shahriar; Dastouri, MOHAMMADREZA; Ostadrahimi, Alireza

doi:10.15171/jcvtr.2017.32

The effects of sodium butyrate and inulin supplementation on angiotensin signaling pathway via promotion of Akkermansia muciniphila abundance in type 2 diabetes; A randomized, double-blind, placebo-controlled trial

Roshanravan N., Mahdavi R., Alizadeh E., Ghavami A., Saadat Y. R., Alamdari N. M., ...Daha Fazla

JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, cilt.9, sa.4, ss.183-190, 2017 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9 Sayı: 4
Basım Tarihi: 2017
Doi Numarası: 10.15171/jcvtr.2017.32
Dergi Adı: JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
Sayfa Sayıları: ss.183-190
Anahtar Kelimeler: Inulin, Sodium Butyrate, TNF-alpha, Akkermansia muciniphila, Diabetes, Angiotensin Signaling Pathway, C-REACTIVE PROTEIN, DIET, INFLAMMATION, MICROBIOTA, HYPERTENSION, OBESITY
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Inflammation has a crucial role in the progression of cardiovascular disease in diabetes. Tumour necrosis factor-alpha (TNF-alpha) as an inflammatory marker induces angiotensin II (Ang II) related hypertension pathway in diabetic patients. Gut modulation via prebiotics may ameliorate hypertension caused by inflammation. The aim of this study was to investigate the role of sodium butyrate (NaBut) and inulin supplements on inflammatory and oxidative stress parameters in type 2 diabetic patients.