POMC expression of the urothelium of the urinary bladder of mice submitted to pelvic radiation

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ÖZBİLGİN M. K., Aktas C., Temel M., Onal T., TÜRKÖZ ULUER E., VATANSEVER H. S., ...Daha Fazla

EUROPEAN JOURNAL OF INFLAMMATION, cilt.14, sa.1, ss.34-39, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1177/1721727x15624698
  • Dergi Adı: EUROPEAN JOURNAL OF INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.34-39
  • Anahtar Kelimeler: bladder, histochemistry, immunohistochemistry, proopiomelanocortin, urothelium, MOUSE BLADDER, DIFFERENTIAL EXPRESSION, TIGHT JUNCTIONS, L-GLUTAMINE, HUMAN SKIN, PROOPIOMELANOCORTIN, PROLIFERATION, PEPTIDES, INJURIES, DAMAGE
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Patients who have had pelvic radiotherapy as part of their cancer therapy may develop subsequent urinary bladder injury. The acute changes that the urothelium undergo after radiation are known, but the healing mechanism of the urothelium of the urinary bladder after pelvic radiotherapy is not clearly understood. Proopiomelanocortin (POMC) peptides, which have immunomodulatory effects, are produced locally in sites outside of the central nervous system. This study aims to determine the role of POMC expression in the urothelium during radiation injury.