POMC expression of the urothelium of the urinary bladder of mice submitted to pelvic radiation

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ÖZBİLGİN M. K., Aktas C., Temel M., Onal T., TÜRKÖZ ULUER E., VATANSEVER H. S., ...More

EUROPEAN JOURNAL OF INFLAMMATION, vol.14, no.1, pp.34-39, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1177/1721727x15624698
  • Journal Name: EUROPEAN JOURNAL OF INFLAMMATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.34-39
  • Keywords: bladder, histochemistry, immunohistochemistry, proopiomelanocortin, urothelium, MOUSE BLADDER, DIFFERENTIAL EXPRESSION, TIGHT JUNCTIONS, L-GLUTAMINE, HUMAN SKIN, PROOPIOMELANOCORTIN, PROLIFERATION, PEPTIDES, INJURIES, DAMAGE
  • Ankara University Affiliated: Yes

Abstract

Objective: Patients who have had pelvic radiotherapy as part of their cancer therapy may develop subsequent urinary bladder injury. The acute changes that the urothelium undergo after radiation are known, but the healing mechanism of the urothelium of the urinary bladder after pelvic radiotherapy is not clearly understood. Proopiomelanocortin (POMC) peptides, which have immunomodulatory effects, are produced locally in sites outside of the central nervous system. This study aims to determine the role of POMC expression in the urothelium during radiation injury.