The impact of granulocyte colony stimulating factor at content of donor lymphocytes collected for cellular immunotherapy

Arat M., Arslan O., GÜRMAN G., Dalva K., Ozcan M., Ugur A., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.30, sa.1, ss.9-15, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.transci.2003.05.004
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9-15
  • Anahtar Kelimeler: donor lymphocyte infusion (DLI), G-CSF (filgrastim), CD34 positive cells, CD3 positive cells, lymphocyte apheresis, BONE-MARROW-TRANSPLANTATION, CHRONIC MYELOID-LEUKEMIA, LEUKOCYTE INFUSION, PROGENITOR CELLS, HEMATOLOGIC MALIGNANCIES, ADOPTIVE IMMUNOTHERAPY, T-LYMPHOCYTES, RELAPSE, APHERESIS, CHEMOTHERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and objectives: Donor lymphocyte infusions (DLI) have become widely used for prevention or treatment of relapse after allogeneic hematopoietic stem cell transplantation. Increasing use of reduced intensity conditioning regimens (RICR) and subsequent application of DLI forced the hemapheresis centers to collect donor lymphocytes in certain quantity and quality. The place of growth factors especially granulocyte colony stimulating factor (rhG-CSF, filgrastim) in allogeneic hemapoietic stem cell (HSC) collection is established, but there is no consensus about the role of rhG-CSF. We aimed to clarify the dose effect of rhG-CSF on lymphocyte subpopulations (CD3+, CD3+4+, CD3+8+, CD19+, CD3-16+56+) cells and CD34+ HSC.