Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.45, sa.3, ss.699-721, 2021 (Scopus)
© 2021 University of Ankara. All rights reserved.Objective: The use of skin models is of great importance in the design and optimization of formulations applied to the skin for topical or systemic effects. Although rat or pig skin is often used in skin penetration/permeation studies of active substances, the compatibility of results obtained from animal skin and human skin is questioned. On the other hand, the use of human skin is limited since it is difficult to attain and due to the ethical concerns. This situation increases the importance of in vitro skin permeation tests. In this review, the advantages and disadvantages of the most commonly used in vitro skin models were emphasized, and current studies performed with these models were reviewed. Result and Discussion: Artificial membranes are preferred over human and animal skin due to many advantages such as reproducibility, low cost, ease of use and able to modify. Reconstructed human skin equivalents have advantages such as high data repeatability, nonnecessity of ethics committee approval and availability for the evaluation of skin metabolism, corrosion and phototoxicity. Despite all these advantages of reconstructed human skin equivalents and important steps in their development, it is not yet entirely possible replacing human or animal skin completely for in vivo estimation of absorption of active ingredients through the skin. The most important factors limiting the use of reconstructed skin models are their high cost and low barrier functions.