Akademik Veri Yönetim Sistemi
60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, İtalya, 15 - 17 Eylül 2022, ss.235
ntroduction: Chronic inflammation is closely associated with
metabolic disorders such as obesity, insulin resistance and Type 2
DM, and is dependent on abnormal cytokine production and
activation of inflammatory signaling pathways. Adipose tissue is a
metabolically active organ that can be a source of low-grade
chronic inflammation in obese individuals. Our aim in this study;
to determine whether there are changes in proinflammatory and
antiinflammatory cytokine levels in obese/overweight and Type 2
diabetes mellitus children and to evaluate their relationship with
clinical and laboratory findings and body fat distribution.
Materials and Methods: The study included 44 (50%) obese/
overweight, 16 (18.2%) Type 2 Diabetes patients and 28 (31.8%)
healthy children with normal body mass index (BMI), between the
ages of 10-18 who applied to the Pediatric Endocrinology Clinic.
TNF-α, IL-1β, IL-6, IL-18 and IFN-γ as proinflammatory markers;
TGF-β and IL-10 levels as antiinflammatory markers were studied.
Subcutaneous, preperitoneal and visceral fat tissue thickness was
measured by abdominal ultrasonography in the obese/overweight
group and Type 2 DM group, and the presence and degree of hepatosteatosis were evaluated.
Results: Age and gender distribution was similar between the
groups. While all 16 patients in the Type 2 DM group had a family
history of diabetes, 31 (70.5%) of 44 obese/overweight patients had
a family history of diabetes (p=0.013). While hepatosteatosis was
present in all cases in the Type 2 DM group, hepatosteatosis was
detected in 36 cases (81.8%) in the obese/overweight group.
High density lipoprotein (HDL) cholesterol was lower in the
Type 2 DM group than in the obese/overweight group (p=0.016).
While visceral and preperitoneal adipose tissue thickness was similar to the obese/overweight group in the Type 2 DM group, subcutaneous adipose tissue thickness was higher than the obese/
overweight group (p=0.021). Subcutaneous adipose tissue thickness and HDL cholesterol were significantly negatively correlated
in the Type 2 DM group (p=0.003, r=-0.684). TGF-β level was significantly lower in the Type 2 DM group than the control group
(p=0.039), and there was no difference between the groups in other
cytokine levels. There was no significant correlation between
TGF-β level and clinical findings and laboratory variables in the
type 2 DM group.
Conclusion: TGF-β level was found to be lower than the control
group in children with Type 2 DM. It was thought that the change
in TGF-β level might have a role in the pathogenesis of Type 2 DM