The Effects of Epigallocatechin Gallate and N-Acetylcysteine on Mobile Phone-Induced Oxidative Stress in Guinea Pigs


KISMALI G., ÖZGÜR BÜYÜKATALAY E., Sayiner S., Alpaslan B., GÜLER ÖZTÜRK G., Seyhan N., ...Daha Fazla

JOURNAL OF ANIMAL AND VETERINARY ADVANCES, cilt.8, sa.5, ss.959-961, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.3923/javaa.2009.959.961
  • Dergi Adı: JOURNAL OF ANIMAL AND VETERINARY ADVANCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.959-961
  • Anahtar Kelimeler: Epigallocatechin gallate, n-acetylcysteine, oxidative stres, mobile phone, guinea pigs, MDA, ACID PHENETHYL ESTER, ACETYL-L-CYSTEINE, LIPID-PEROXIDATION, ANTIOXIDANT ACTIVITY, MECHANISM, TOXICITY
  • Ankara Üniversitesi Adresli: Evet

Özet

It has been reported that mobile phones induce free radical formation. Epigallocatechin Gallate (EGCG) and N-Acetylcysteine (NAC) were recently found to be potent antioxidants. The present study was carried out to determine the protective effects of antioxidants namely EGCG and NAC against the mobile phone-induced oxidative stress. Three-month-old male Guinea pigs were randomized into 6 groups; sham group, not exposed to mobile phone, NAC group (300 mg kg(-1) ip, 7 days), 10 min mobile phone-exposed group with NAC, 10 min mobile phone-exposed group, EGCG group (25 mg kg(-1) ip, 7 days) and 10 min mobile phone-exposed group with EGCG. During the exposure external E fields were measured by NARDA EMR 300 and type 8.3 probe. Guinea pigs were exposed to RFR averaged as 11.2 +/- 0.5 V m(-1) for 10 min/day/7days. Malondialdehyde (MDA, an index of lipid peroxidation) were analysed as markers of oxidative stress. Plasma MDA levels increased in mobile phone exposed guinea pigs while EGCG causes a significant reduction of MDA levels, whereas NAC caused a significant increase in MDA levels. Also, MDA levels in mobile phone exposure group significantly increased with respect to sham exposure group. A number of studies have identified antioxidant species which show antioxidant effect in low-dose and pro-oxidant behaviour in high-dose. The increase of the lipid peroxidation at the treatment dose of NAC in guinea pigs may possibly be due to pro-oxidant behaviour. Besides, this study expressed that mobile phone exposure affect the level of lipid peroxidation of plasma.