Akademik Veri Yönetim Sistemi
21st International Conference on Diseases of Fish and Shellfish, Aberdeen, İngiltere, 11 - 15 Eylül 2023, ss.128
Introduction: Aquaculture is a rapidly growing industry that provides a significant proportion of the world's fish supply. The use of antimicrobials in aquaculture is essential for controlling bacterial infections and maintaining fish health. However, the overuse and misuse of antimicrobials in aquaculture can lead to the emergence and spread of antimicrobial resistance (AMR), posing a significant threat to public health and the sustainability of the industry. Antimicrobial dose optimization is a key strategy for reducing the risk of AMR while maintaining treatment efficacy in aquaculture.
Methodology: This review paper provides a comprehensive overview of the current state of knowledge regarding antimicrobial dose optimization in aquaculture. The paper synthesizes the existing literature on the topic and discusses the various factors that affect antimicrobial dose optimization in aquaculture, including the species, size, and life stage of the animals, as well as environmental factors such as water quality and temperature. The review highlights the importance of considering both the benefits and risks of antimicrobial use in aquaculture and provides guidance on how to balance treatment efficacy and AMR risk through dose optimization.
The paper presents the different methods for determining optimal antimicrobial doses, including in vitro assays and in vivo experiments, as well as pharmacokinetic and pharmacodynamic modeling. The review also discusses the challenges and limitations of antimicrobial dose optimization in aquaculture, such as the lack of standardized protocols and the need for further research to address data gaps.
Conclusions: Overall, this review paper provides a valuable resource for researchers, policymakers, and practitioners involved in the development of sustainable and effective disease management strategies in aquaculture. The paper emphasizes the importance of antimicrobial dose optimization in reducing the risk of AMR and provides practical recommendations for optimizing antimicrobial use in aquaculture while maintaining treatment efficacy.