Synthesis, antioxidant and radical scavenging activities of novel benzimidazoles

KILCIGİL G., Ku C., Coban T., Can-Eke B., Ozbey S., Iscan M.

Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.20, sa.5, ss.503-514, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/14756360500287086
  • Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.503-514
  • Anahtar Kelimeler: thiosemicarbazides, thiadiazolylmethylbenzimidazoles, triazolylmethylbenzimidazoles, antioxidant activity, X-ray structure analysis, radical scavenging, LIPID PEROXIDE FORMATION, DERIVATIVES, MECHANISMS, INDOLE, LIVER
  • Ankara Üniversitesi Adresli: Evet

Özet

The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10-24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17-18 -fold more potent than BHT (IC50 2.3 × 10-4M) with 1.3 × 10-5M and 1.2 × 10-5M IC50 values, respectively, by interaction of the stable DPPH free radical. © 2005 Taylor & Francis.