Research Information System
Turkish Journal of Gastroenterology, vol.7, no.4, pp.331-334, 1996 (SCI-Expanded)
Helicobacter pylori is presently considered as a major factor predisposing to the development of duodenal ulceration. The exact mechanism by which Helicobacter pylori contributes to mucosal damage is unknown. In this study, 9 patients with Helicobacter pylori (+) duodenal ulcers were examined by means of 24 h intragastric pH and serum gastrin concentrations before and after the eradication of the organism in order to investigate the role of Helicobacter pylori in peptic ulcer disease. After eradication of Helicobacter pylori there was an increase in 24 h mean and median pH of the patients. The median and mean pH raised significantly from 1.63 ± 0.08 to 1.87 ± 0.06 and from 1.95 ± 0.12 to 2.32 ± 0.13, respectively (p<0.05). There was a slight but statistically insignificant decrease in serum gastrin after treatment. These findings suggest that Helicobacter pylori infection increases intragastric acidity.