The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: Possible role of cyclooxygenase-2 induction

Akarsu E. S., Ozdayi S., Algan E., Ulupinar F.

EPILEPSY RESEARCH, cilt.71, sa.2-3, ss.181-187, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 2-3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.eplepsyres.2006.06.009
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.181-187
  • Anahtar Kelimeler: acute phase response, convulsion, cyclooxygenase-1, cyclooxygenase-2, valeryl salicylate, SC-58236, BLOOD-BRAIN-BARRIER, PROSTAGLANDIN E-2, MESSENGER-RNA, MOUSE-BRAIN, RAT-BRAIN, ENDOTOXIN, CONVULSIONS, INHIBITORS, INVOLVEMENT, EXPRESSION
  • Ankara Üniversitesi Adresli: Evet

Özet

The parameters of pentylenetetrazol (PTZ)-induced seizures have been evaluated at various time intervals after lipopolysaccharide (LPS; Escherichia coli O111:B4, 100 mu g/kg, i.p.) administration in mice. A proconvulsant effect occurred 4 h after LPS injection with decreased seizure latency and enhanced seizure intensity. In contrast, the incidence of seizures was reduced 18 h after LPS injection. There were no significant alterations on seizure parameters 2, 8, 12, and 24 h after LPS treatment. SC-58236, a selective cyclooxygenase (COX)-2 inhibitor (20 or 40 mg/kg, s.c.) treatment alone had no effect on PTZ-induced seizures, but reversed the antiseizure activity observed 18 h after LPS injection. However, SC-58236 treatment partially restored the proconvulsant changes that were observed 4 It after LPS administration. On the other hand, COX-1-selective inhibitor valeryl salicylate (20 or 40 mg/kg, s.c.) itself facilitated PTZ-induced seizures. Thus, it was not possible to evaluate the effects of valeryl salicylate on the excitability changes after LPS injection. These results indicate that the parameters of PTZ-induced seizures change time-dependently after LPS treatment, in which proconvulsant and anticonvulsant states could be seen in a sequence. It seems that COX-2 isoenzyme may be involved in the neuronal excitability changes due to LPS. (c) 2006 Elsevier B.V. All rights reserved.