Akademik Veri Yönetim Sistemi
KLEINTIERPRAXIS, cilt.46, sa.3, ss.141-149, 2001 (SCI-Expanded)
The aim of the present study was to proof effectiveness as well as side effects of the combinatory use of the dopamine agonist cabergoline and the prostaglandin F-2 alpha analog alfaprostol for terminating unwanted pregnancies in the bitch. The animals were randomly assigned to 4 treatment groups: group A - 20 mug alfaprostol/kg body mass (BM) and 5 mug cabergoline/kg BM; group B - 10 mug alfaprostol/kg BM and 5 mug cabergoline/kg BM; group C - 5 mug alfaprostol/kg BM and 5 mug cabergoline/kg BM; group D - 1 mug cloprostenol/kg BM and 5 mug cabergoline/kg BM. The owner administered oral doses of cabergoline daily and a veterinarian injected the PGF(2 alpha)-agonist intramuscularly every second day in the clinic. Treatment terminated pregnancy in all dogs (n = 20): 2 of them exhibited abortion, 6 bitches showed abortion of some fetuses as well as resorption of the remaining ones, but resorption of all fetuses took place in 12 cases. Side effects of the treatment decreased with reduced alfaprostol dose. All group-A bitches vomited after each application of alfaprostol, in contrast to group C: 2 animals showed no side effects and only one bitch vomited after each treatment. Side effects were also alleviated in group B, when compared with group A. In general, the animals responded to cloprostenol by exhibiting more serious side effects (group D) than in all other groups. Combined application of 5 mug alfaprostol/kg BM and 5 mug cabergoline/kg BM is able to terminate unwanted pregnancies in the bitch. Treatment can be started, when pregnancy is detected first by sonography. Advantages for the use of the tested medication in veterinary practice are high eEfectiveness as well as mild side effects.