Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility

Kocabas N., Sardas S., Cholerton S., Daly A., ELHAN A. H., Karakaya A.

CELL BIOCHEMISTRY AND FUNCTION, cilt.23, sa.1, ss.73-76, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/cbf.1128
  • Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-76
  • Anahtar Kelimeler: MnSOD genetic polymorphism, breast cancer, free radical, oestrogen, Turkish population, ANTIOXIDANTS, CELLS
  • Ankara Üniversitesi Adresli: Evet

Özet

Within mitochondria, manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species (ROS). An alanine-9valine (Ala-9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer. Our present case-control study was performed to explore the association between MnSOD genetic polymorphism and individual susceptibility to breast cancer. Ala-9Val polymorphism in the signal sequence of the protein for MnSOD was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a study population. There was no significant difference in risk for breast cancer development between patients positive and negative for the MnSOD Ala allele with adjusted odds ratio (OR): 0.86 (95% confidence interval (CI) 0.43 to 1.72). When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferase COMT-L (V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index (BMI) greater than 24 kg m(-2) (OR: 1.42 (95%CI = 1.04-1.93)). Copyright (C) 2004 John Wiley Sons, Ltd.