Evaluation of long-term follow-up and methimazole therapy outcomes of pediatric Graves' disease: a single-center experience

Bayramoglu E., Elmaogullari S., Sagsak E., AYCAN Z.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.32, no.4, pp.341-346, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1515/jpem-2018-0495
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.341-346
  • Keywords: children, Graves' disease, long-term outcome, methimazole treatment, remission, ANTITHYROID DRUG-TREATMENT, CHILDREN, HYPERTHYROIDISM, REMISSION, MANAGEMENT, ADOLESCENTS, PREDICTORS
  • Ankara University Affiliated: Yes

Abstract

Background: The management options for Graves' disease in children are limited and there is controversy regarding optimal treatment. Remission rate with anti-thyroid drug (ATD) treatment in children is said to be lower than in adults. Definitive treatments are effective, but they often result in permanent hypothyroidism. The objective of this study was to investigate the outcome of methimazole treatment, identify significant predictors of a remission and evaluate the adverse effects of methimazole in a pediatric population of GD patients.