Melatonin and synthetic analogs as antioxidants


SÜZEN S.

Current Drug Delivery, vol.10, no.1, pp.71-75, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 10 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.2174/1567201811310010013
  • Journal Name: Current Drug Delivery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.71-75
  • Keywords: Antioxidant, Free radical, Indole, Melatonin, Synthesis
  • Ankara University Affiliated: Yes

Abstract

Recent studies suggest that overproduction of reactive oxygen and nitrogen species (ROS/RNS), lowered antioxidant defense of the body. Oxidative stress is damaging to DNA, lipids, proteins and many more vital macromolecules. Consequences of oxidative stress thought to contribute to the development of a wide range of diseases including Alzheimer's disease, Parkinson's disease, diabetes, rheumatoid arthritis, neurodegeneration in motor neuron diseases and many cancer types. Melatonin (MLT) is a powerful antioxidant with a particular role in the protection of nuclear and mitochondrial DNA. To find an improved antioxidant activity, developments of novel synthetic analogues are under investigation. These studies may offer a new progress and approach in antioxidant drug development as well as antioxidant chemistry. Therefore, we have been synthesizing novel MLT derivatives and investigating their antioxidant capacities. This review gives a brief knowledge about the MLT based analogue indole derivatives as potential antioxidants. © 2013 Bentham Science Publishers.