The effects of short-term training on platelet functions and total antioxidant capacity in rats

FIÇICILAR H., ZERGEROĞLU A. M., Ersoz G., Erdogan A., ÖZDEMİR S., Tekin D.

PHYSIOLOGICAL RESEARCH, cilt.55, sa.2, ss.151-156, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 2
  • Basım Tarihi: 2006
  • Dergi Adı: PHYSIOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.151-156
  • Anahtar Kelimeler: exercise, antioxidant capacity, platelet, aggregation, secretion, OXIDATIVE STRESS, ACUTE EXERCISE, ISCHEMIA-REPERFUSION, MYOCARDIAL TOLERANCE, POSSIBLE INVOLVEMENT, PHYSICAL-ACTIVITY, CARDIOPROTECTION, RESPONSIVENESS, RELEASE, LDL
  • Ankara Üniversitesi Adresli: Evet

Özet

The purpose of the present study was to investigate the effect of short-term endurance training on plasma total antioxidant status (TAS) and on in vitro platelet aggregation and ATP release. Blood samples were collected from the abdominal aorta of rats following short-term treadmill exercise (25 m/min, 0 % grade, 30 min) for three consecutive days, as well as in non-exercised control group. Platelet aggregation and platelet ATP release were evaluated by impedance and bioluminescence techniques, respectively. Plasma TAS was measured spectrophotometrically. Plasma TAS was higher and ADP-induced platelet ATP release was lower in the short-term training group with respect to the control group (p < 0.001). Significant negative correlation (r = -0.56, p < 0.05) was found between plasma TAS and ADP-induced platelet ATP release. Neither ADP- and collagen-induced maximum aggregation rate nor collagen-induced platelet ATP release were significantly different between the groups. According to these results, short-term training caused an alteration in platelet functions limited to the secretion response, which may be related to the oxidant/antioxidant balance changes favoring the antioxidants. The improved plasma total antioxidant capacity was possibly sufficient to prevent exercise-induced oxidative damage, and the adaptive response of platelets might be associated with enhanced antioxidant status.