Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, sa.5, ss.2801-2803, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2013
- Doi Numarası: 10.7314/apjcp.2013.14.5.2801
- Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2801-2803
- Anahtar Kelimeler: ABO blood, group system, lung neoplasms, cancer, risk factors, GENOME-WIDE ASSOCIATION, VON-WILLEBRAND-FACTOR, GROUP ANTIGEN-A, VENOUS THROMBOEMBOLISM, EXPRESSION, SURVIVAL, VARIANTS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. Results: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. Conclusions: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.