Secondary hemophagocytic lymphohistiocytosis in Turkish children

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Gurgey A., Secmeer G., Tavil B., Ceyhan M., Kushkonmaz B., Cengiz B., ...More

PEDIATRIC INFECTIOUS DISEASE JOURNAL, vol.24, no.12, pp.1116-1117, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1097/01.inf.0000190043.48182.31
  • Journal Name: PEDIATRIC INFECTIOUS DISEASE JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1116-1117
  • Keywords: secondary hemophagocytic lyrnphohistiocytosis, frequency of hemophagocytic lymphohistiocytosis, bacterial infection, viral infection, cytomegalovirus infection, PERFORIN GENE-MUTATIONS, INFECTION
  • Ankara University Affiliated: No

Abstract

Between January 1998 and January 2005, a total of 18 children 2 weeks-72 months of age were diagnosed as having secondary hemophagocytic lymphohistiocytosis. The frequency of secondary hemophagocytic lymphohistiocytosis among total hospitalized patients during this period was 0.05% (18 of 34,250). Of the 18 patients, 8 (44.5%) had bacterial infections; cytomegalovirus and Epstein-Barr virus infections were present in 5 (28%) and 1 (5.5%), patient, respectively. Leishmaniasis was diagnosed in 2 patients (11%), and herpes simplex virus was diaganosed in 2 patients (11%). Six patients died during treatment, and 1 patient was lost to follow-up. The survival rate was 61%.