Akademik Veri Yönetim Sistemi
Kafkas Universitesi Veteriner Fakultesi Dergisi, cilt.15, sa.1, ss.119-124, 2009 (SCI-Expanded)
The present study was investigated the effect of kefir on anastomosis healing and bacterial translocation in rabbits with colonic anastomosis following colon preparation with laxative and antibiotic (AB) use. For this aim, 16 rabbits were divided into two groups each having 8 rabbits. All rabbits had prepared for surgery and received preoperative antibiotics. Control group received standard rabbit diet and water. The experimental group received 30 ml/kg kefir per day in addition to standard feeding, for 5 days before and after the operation. Right colonic resection and end-to-end anastomosis were done in both groups. Anastomosis bursting pressure and bacterial translocation were investigated on the fifth day after the operation. Also, histopathological evaluation was done. No bacterial growth was observed in blood cultures. However, mesenteric lymph node samples showed bacterial growth in two rabbits (one from each group). Mean anastomosis bursting pressure was 85.0±17.5 mmHg and 133.75±25.03 mmHg in the control and experimental group, respectively, with a statistically significant difference (P<0.01). Histopathological examination of the sections from the anastomosis sites revealed similar findings in both groups such as increased connective tissue proliferation and vascularisation. The increased bursting pressure in the experimental group particularly suggests that kefir may contribute to the healing of colonic anastomosis.