Effects of subtenon-injected autologous platelet-rich plasma on visual functions in eyes with retinitis pigmentosa: preliminary clinical results

Arslan U., ÖZMERT E., DEMİREL S., Ornek F., ŞERMET F.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.256, sa.5, ss.893-908, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 256 Sayı: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s00417-018-3953-5
  • Dergi Adı: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.893-908
  • Anahtar Kelimeler: Retinitis pigmentosa, Growth factors, Platelet-rich plasma, Visual functions, CORD SERUM EYEDROPS, NERVE GROWTH-FACTOR, RETINAL DEGENERATION, CONE PHOTORECEPTORS, ECTOPIC SYNAPTOGENESIS, FOLLOW-UP, RHODOPSIN, SURVIVAL, MOUSE, NGF
  • Ankara Üniversitesi Adresli: Evet

Özet

One of the main reasons for apoptosis and dormant cell phases in degenerative retinal diseases such as retinitis pigmentosa (RP) is growth factor withdrawal in the cellular microenvironment. Growth factors and neurotrophins can significantly slow down retinal degeneration and cell death in animal models. One possible source of autologous growth factors is platelet-rich plasma. The purpose of this study was to determine if subtenon injections of autologous platelet-rich plasma (aPRP) can have beneficial effects on visual function in RP patients by reactivating dormant photoreceptors.