Fatal bone marrow necrosis following fludarabine administration in a patient with indolent lymphoma

Aboulafia D. M., DEMİRER T.

Leukemia and Lymphoma, cilt.19, sa.1-2, ss.181-184, 1995 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1-2
  • Basım Tarihi: 1995
  • Doi Numarası: 10.3109/10428199509059674
  • Dergi Adı: Leukemia and Lymphoma
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.181-184
  • Anahtar Kelimeler: Bone marrow necrosis, Clinical picture, Fludarabine, Pathogcnehis
  • Ankara Üniversitesi Adresli: Evet

Özet

We report the first known case of fulminant bone marrow necrosis (BMN) occurring after infusion of fluduabine monophosphate in a patient with recurrent low-grade non-Hodgkin's lymphoma (NHL). Extensive BMN is characterized by the development of fever, bony pain. a leukoerythroblastic peripheral blood film, variable degrees of pancytopenia and elevations in lactate dehydrogcnase and alkaline phosphatase. The diagnosis of BMN is rarely entertained ante-mortem. Although the precise role chemotherapy may have played in triggering fatal BMN remains speculative, we alert clinicians to be aware of this entity as more patients with indolent lymphomas and leukemias are treated with this and other potent nucleoside analogs. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.