Serum IFN-gamma and IL-10 levels before and after specific immunotherapy in patients with allergic rhinitis.

Keskin G., Inal A., Ali Sari R., Şengül A., ŞAHİN M., Turgay M., ...Daha Fazla

Allergologia et immunopathologia, cilt.27, sa.5, ss.261-4, 1999 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 5
  • Basım Tarihi: 1999
  • Dergi Adı: Allergologia et immunopathologia
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.261-4
  • Anahtar Kelimeler: Allergic rhinitis, IL-10. IFN-γ, Immunotherapy
  • Ankara Üniversitesi Adresli: Evet

Özet

Althoug a detailed explanation of the mechanism of immunotherapy is not known, several immunologic explanation have been proposed. It's said that T cellcytokine profile changed with allergen immunotherapy. In our study we evaluated IFN-γ and IL-10 levels before and after immunotherapy in patients with allergic rhinitis. Twenty patients (mean age; 27.3 ± 4.84), 8 male, 12 female with allergic rhinitis, mean duration of disease was 5.55 ± 1.23 years and 13 healthy controls, 5 male, 8 female (mean age: 28.38 ± 5.61) were enrolled in the study. Immunotherapy was performed for grass pollen allergen extract to patients with allergic rhinitis for 31.5 ± 4.98 months. Serum IL-10 and IFN-γ levels were evaluated with ELISA. Serum IL-10 levels were significantly high before and after immunotherapy compared to controls. There was no difference in IFN-γ levels before and after SIT compared to controls. According to this study, in patients with allergic rhinitis after immunotherapy serum IL-10 levels are decreased but IFN-γ no change.