Effect of scoring design on the uniformity of extended release matrix tablet halves

Duman E., Yuksel N., Olin B., Sakr A.

PHARMAZEUTISCHE INDUSTRIE, cilt.62, sa.7, ss.547-550, 2000 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 7
  • Basım Tarihi: 2000
  • Dergi Adı: PHARMAZEUTISCHE INDUSTRIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.547-550
  • Anahtar Kelimeler: extended release, half tablets, uniformity, matrix tablets, scoring design, DISSOLUTION, STATISTICS
  • Ankara Üniversitesi Adresli: Evet

Özet

API030611 is an antiaxiety agent that needs to be titrated/adjusted relative to patients' responses and tolerances. The research objective was to evaluate the effect of scoring design on weight and content uniformity and dissolution of the extended release matrix tablet halves. Various scoring designs of capsule shaped tablets were evaluated. Ten subjects varying in age, weight and gender broke the scored tablets the same way like in the usual life. Certain scoring designs produced qualitatively more uniform tablet halves; there were no statistical differences due to scoring design, age, weight and gender. The most reproducible tablet halves were produced using the design of top and bottom scoring Independent of the type (deep, shallow) of the scoring.