Synthesis and biological activity of some new flavone derivatives

Bozdag-Dundar O., Ceylan-Unlusoy M., ALTANLAR N., Ertan R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.55, sa.2, ss.102-106, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1055/s-0031-1296830
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.102-106
  • Anahtar Kelimeler: flavone derivatives, anti-fungal and antimicrobial activities, synthesis, ANTIBACTERIAL, INVITRO
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a new series of 2-{4-[substituted benzylamino-methyl}-phenyl]-4H-benzopyrane-4-one (IVa-e) and N-substituted benzyl-N-[4-(4-oxo-4H-benzopyrane-2-yl)benzyl]-3-phenyl-acrylamide (Va-e) derivatives was synthesized and the results of their biological activity are reported. The synthesized compounds were tested for their in vitro antifungal and antibacterial activities. Compound IVa showed the best antifungal activity compared with miconazole (CAS 22916-47-8). Compound We indicated the same antibacterial activity compared with the control drug ampicillin (CAS 69-53-4).