Impact of COVID-19 pandemic on antidepressants consumptions by wastewater analysis in Turkey

Yavuz-Guzel E., Atasoy A., GÖREN İ. E., DAĞLIOĞLU N.

SCIENCE OF THE TOTAL ENVIRONMENT, cilt.838, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 838
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.scitotenv.2022.155916
  • Dergi Adı: SCIENCE OF THE TOTAL ENVIRONMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Analytical Abstracts, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, MEDLINE, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Wastewater-based epidemiology (WBE), COVID-19, Antidepressants, Drug consumption rate changes, CLINICAL PHARMACOKINETICS, AMITRIPTYLINE, METABOLISM, IMIPRAMINE, CLOMIPRAMINE, MIRTAZAPINE, VENLAFAXINE, EXCRETION, URINE
  • Ankara Üniversitesi Adresli: Evet

Özet

The COVID-19 pandemic has been a major challenge worldwide, forcing countries to take restrictive measures beyond conventional methods in their fight against the spread of the disease. Followingly, many studies have been conducted on the effects of these measures on mental health. Wastewater-based epidemiology (WBE) was used in this study to monitor and estimate changes in antidepressant use under normal conditions (2019) and COVID-19 pandemic condi-tions (2020). Likewise, this study utilized wastewater-based epidemiology (WBE) to monitor and assess changing trends from the pre-pandemic period (2019) to COVID-19 pandemic conditions in antidepressant use (2020).Wastewater samples were collected from 11 cities in Turkey throughout six sampling periods covering the pre-pandemic and during-pandemic periods (June 2019-December 2020). Then, samples were analyzed via LC-MS/MS method. As a result, we observed that venlafaxine was the drug with the highest concentration (mean +/- SD: 103.6 +/- 112.1 mg/1000p/day). Moreover, city number 6 presented the highest venlafaxine use and the most dramatic in-crease during the pandemic period. Finally, this study revealed the potential of WBE to estimate the changing trends in mental health during the ongoing pandemic.