Natural killer cell numbers and cytotoxic activity in pediatric Hodgkin disease

İKİNCİOĞULLARI K. A., DOĞU E. F., Babacan E., Oflaz G., Ertem U., Yavuz G., ...Daha Fazla

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.17, sa.2, ss.133-139, 2000 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1080/088800100276488
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.133-139
  • Anahtar Kelimeler: children, cytotoxic activity, Hodgkin disease, NK cell, CYTO-TOXICITY, LYMPHOMA, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study peripheral blood natural killer (NK) cell activity was evaluated in 17 pediatric cases with Hodgkin disease (HD) (9 untreated, 8 in remission) and 20 age-matched healthy children. Peripheral Blood CD16 and CD56 molecule expressions were also examined. No difference related to NK cell numbers and cytotoxic activity was detected at either stage of the disease. In cases in which long-term remission has been achieved (greater than or equal to 5 years) NK cell activity was slightly but not significantly increased in parallel with remission duration. Finally, no relation between NK cell activity and the etiology, prognosis, and severity of the disease has Been established in children with HD.