Natural killer cell numbers and cytotoxic activity in pediatric Hodgkin disease

İKİNCİOĞULLARI K. A., DOĞU E. F., Babacan E., Oflaz G., Ertem U., Yavuz G., ...More

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.17, no.2, pp.133-139, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1080/088800100276488
  • Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.133-139
  • Keywords: children, cytotoxic activity, Hodgkin disease, NK cell, CYTO-TOXICITY, LYMPHOMA, CANCER
  • Ankara University Affiliated: Yes

Abstract

In this study peripheral blood natural killer (NK) cell activity was evaluated in 17 pediatric cases with Hodgkin disease (HD) (9 untreated, 8 in remission) and 20 age-matched healthy children. Peripheral Blood CD16 and CD56 molecule expressions were also examined. No difference related to NK cell numbers and cytotoxic activity was detected at either stage of the disease. In cases in which long-term remission has been achieved (greater than or equal to 5 years) NK cell activity was slightly but not significantly increased in parallel with remission duration. Finally, no relation between NK cell activity and the etiology, prognosis, and severity of the disease has Been established in children with HD.