Akademik Veri Yönetim Sistemi
22nd European Section Meeting of the International-Society-for-Heart-Research, Szeged, Macaristan, 3 - 06 Temmuz 2002, ss.55-59
Experiments have shown that resveratrol can induce vascular relaxation both directly and in an endothelium-dependent manner. This study researched the mechanisms behind the effects of resveratrol on vascular smooth muscle in the rat aorta. Resveratrol (10(-4) M) potentiated acetylcholineinduced relaxation of the vessel wall, but had no effect on sodium nitroprusside-induced relaxation. Resveratrol (10(-4) M) depressed muscle contractions induced by phenylephrine, potassium chloride, and calcium ionophore A-23187 in endothelium-denuded aortic rings. The results indicate that the effect of resveratrol on vascular tone is related to elevated levels of endothelium-derived nitric oxide, and to direct inhibition of excitation-contraction coupling in smooth muscle cells.