Erythrocyte antigen and reticulocyte engraftment after allogeneic hematopoietic stem cell transplantation

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Yildirim I., Ozer Y., YÜKSEL M., Arat M., Arslan O.

BONE MARROW TRANSPLANTATION, cilt.34, sa.4, ss.351-355, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1038/sj.bmt.1704576
  • Dergi Adı: BONE MARROW TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.351-355
  • Anahtar Kelimeler: hematopoietic stem cell transplantation, engraftment, erythrocyte antigen, reticulocyte, chimerism, BONE-MARROW-TRANSPLANTATION, FRAGMENT-LENGTH-POLYMORPHISMS, HEMATOLOGIC MALIGNANCIES, FLOW-CYTOMETRY, CHIMERISM, POPULATIONS, REPOPULATION, RELAPSE, MARKERS, HOST
  • Ankara Üniversitesi Adresli: Hayır

Özet

The aim of this study was to study the usefulness of erythrocyte antigen (EA) measurement to study engraftment after allogeneic HSCT. In all, 31 consecutive patients receiving HLA-identical bone marrow (BM) (n = 13) or peripheral blood stem cells (n = 18) were investigated. Apart from the ABO group, 15 EAs representing six minor blood groups were followed by the simple tube agglutination technique. A total of 20 (64.5%) patients received ABO-identical, eight (25.8%) received ABO minor and three (9.7%) received ABO major mismatched grafts. In all, 29 patients were followed for a median of 12 (6-16) months; 65% of the patients expressed donor type EA 1 month and almost all did so 6 months after transplant. Reticulocyte engraftment was significantly shorter than EA engraftment (median 18 vs 35 days) (P = 0.001). Patients who received PB stem cells showed significantly faster EA and reticulocyte engraftment than patients who received BM stem cells (P = 0.038 and 0.025). ABO compatibility did not have an impact on reticulocyte and EA engraftment (P = 0.4 and 0.55). The earliest donor type EA detected was from the Rh and Kidd system. These data suggest that EA and reticulocyte assays are useful in monitoring engraftment.