Akademik Veri Yönetim Sistemi
BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY, cilt.51, sa.4, ss.497-501, 2007 (SCI-Expanded)
This study was designed to find out whether lesions developing after the vaccination against salmonellosis were the result of an adjuvant action. Four-week-old 41 broiler breeders were assigned randomly to receive a Salmonella Enteritidis vaccine, containing lipid (n=29) or aluminium hydroxide (n=12) adjuvant, injected subcutaneously in the neck region. The birds were sacrificed by cervical dislocation 8 weeks after vaccination for morphological and histopathological evaluation. Diffuse nodular structures of varying sizes with whitish and yellowish pus were observed in the cervical and temporal region of 19 and 7 chickens injected with lipid and aluminium hydroxide adjuvant, respectively. Microscopic evaluation of these nodules revealed that they were granulamotous focuses with coagulation necrosis in the centre surrounded by lime accumulation, necrotic cell residues, and pycnotic heterophilic leukocytes. Moreover, epithelioid histiocytes, lymphocytes, macrophages, and foreign body giant cells were also present peripherally. These cells were encapsulated by fibroblast, fibrocyte, and collagen bundles. The results of this experimental study ascertained the legitimacy of occurrence of post-vaccinal lesions. However, histopathology of the lesions did not differ by the type of the adjuvant.