Synthesis of some novel oxime ether derivatives and their activity in the 'behavioral despair test'

Bozdag O., Gumusel B., Demirdamar R., Buyukbingol E., Rolland Y., Ertan R.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.33, sa.2, ss.133-141, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0223-5234(98)80038-x
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.133-141
  • Anahtar Kelimeler: fluvoxamine, aminoethyloxime ether derivatives, structural analysis behaviora, behavioral despair test, FLUVOXAMINE, ANTIDEPRESSANTS, INHIBITORS
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a new series of 2-aminoethyloxime ether derivatives of some aralkylketones was synthesized. Their structures have been elucidated by UV, IR, H-1-NMR, C-13-NMR, mass spectra and elementary analysis. These compounds were then screened for their inhibition of immobility as an indicator of possible antidepressant activities by using the 'behavioral despair test'. Results showed that all the new compounds decreased the immobility time, however, the inhibition observed with A03, A04 and H01 was significantly higher compared to fluvoxamine (p < 0.01). (C) Elsevier, Paris.