Simultaneous determination of guaiphenesin and codeine phosphate in tablets by high-performance liquid chromatography

SÜZEN H. S., Akay C., Cevheroglu S.

FARMACO, cilt.54, sa.10, ss.705-709, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 10
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0014-827x(99)00086-5
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.705-709
  • Anahtar Kelimeler: guaiphenesin, codeine phosphate, high-performance liquid chromatography, simultaneous determination, tablet, STABILITY-INDICATING ANALYSIS, SODIUM BENZOATE, PHENYLPROPANOLAMINE HYDROCHLORIDE, PHENYLEPHRINE HYDROCHLORIDE, DOSAGE FORMS, GUAIFENESIN, ACETAMINOPHEN, DEXTROMETHORPHAN, SYRUP
  • Ankara Üniversitesi Adresli: Evet

Özet

A reversed-phase high-performance liquid chromatographic method has been developed for the simultaneous determination of guaiphenesin and codeine phosphate in an antitussive tablet formulation. A 10-mu m C-18 column is used with a 1:1 methanol-water mixture (pH 3.0) as the mobile phase and spectrophotometric detection is carried out at 212 nm. The total elution time is shorter than 4.4 min. The method showed good linearity, precision and reproductibility. The proposed method was successfully applied to the determination of guaiphenesin and codeine phosphate in tablets. (C) 1999 Elsevier Science S.A. All rights reserved.