The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study

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SERT İ. Ü., KILIÇ Ö., AKAND M., Saglik L., AVUNDUK M. C., ERDEMLİ E.

ARCHIVES OF MEDICAL SCIENCE, cilt.14, sa.2, ss.381-387, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5114/aoms.2016.60227
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.381-387
  • Anahtar Kelimeler: zoledronic acid, vitamin E, nephrotoxicity, renal function, rat, ACUTE TUBULAR-NECROSIS, BREAST-CANCER, SHORT-TERM, THERAPY, BISPHOSPHONATES, TOLERABILITY, METASTASES, EFFICACY, KIDNEY, WOMEN
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy.